Histopathologic alterations associated with the pathogenesis of periodontal disease include
1. inflammatory exudate that can involve neutrophils, lymphocytes and plasma cells.
2. proliferative and degenerative changes of the junctional epithelium.
3. collagen destruction subjacent to the junctional epithelium.
4. deepening of the gingival sulcus.

All of the above

(1) (2) (3)

(1) and (3)

(2) and (4)

(4) only