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The duration of action of lidocaine would be increased in the presence of which of the following medications?

Propranolol

Prazosin

Hydrochlorothiazide

Lisinopril

Digoxin

1 explanations

Angelok890
Propranolol interacts with lidocaine in two ways. By slowing down the heart via beta receptor blockade, blood delivery (and lidocaine) to the liver is reduced, thus lidocaine remains in the systemic circulation longer, and can potentially accumulate to toxic levels. Propranolol and lidocaine also compete for the same enzyme in the liver, thus metabolism of lidocaine can be reduced.
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