Cardiovascular collapse elicited by a high circulating dose of a local anesthetic may be caused by

1 explanations

1. 

   Angelok890

   Cardiovascular collapse is due to a direct action of the local anesthetic on the heart muscle itself (LA's in toxic doses depress membrane excitability and conduction velocity), thus Myocardial depression is the correct answer. All of the other alternatives are indirect ways to affect the heart.

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