"Epinephrine reversal" of blood pressure can best be demonstrated by injecting epinephrine intravenously after pretreatment with
Prazosin
Atropine
Propranolol
Neostigmine
Isoproterenol
1 explanations
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epinephrine is a potent stimulator of both alpha and beta
receptors. Injection of epi usually causes a rise in blood pressure due to 1) myocardial stimulation that increases ventricular contraction, 2) an increase in heart rate, and most important, 3) vasoconstriction due to alpha receptor stimulation. However, blood flow to skeletal muscles is increased due to powerful beta-2 receptor vasodilator action that is only partially counterbalanced by a vasoconstrictor action on the alpha receptors that are also present in the vascular bed. When given in the presence of an alpha blocker, beta-receptor mediated vasodilation is more pronounced, the total peripheral resistance is decreased and the mean blood pressure falls.This decrease in blood pressure is called "epinephrine reversal". The only alpha-blocker listed is prazosin,
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