Which of the following is most likely to be the major mechanism of action of the tricyclic antidepressants?

Blockade of the reuptake of amine neurotransmitters released into the synaptic cleft

Enhanced release of acetylcholine

Stimulation of reuptake of norepinephrine from the synaptic cleft

Potentiation of serotonin synthesis in nervous tissue

Inhibition of neuronal synthesis of norepinephrine