Use of diphenhydramine (Benadryl ) in controlling the symptoms of parkinsonism is based upon which of the following effects?
Anticholinergic
Local anesthetic
Adrenergic-blocking
CNS depressant on the midbrain
Stimulant to dopaminergic nerves in the basal ganglia
1 explanations
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anticholinergic drugs were he first drugs found to be somewhat effective for treatment of this disease, in that cholinergic and dopaminergic tracts interact in the brain, and thus reducing cholinergic activity via anticholinergic drugs improves or enhances dopaminergic
function, suggesting one is inhibitory to the other. Drugs with anticholinergic activity are often still the first drug tried.
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