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Cephalosporin antibiotics
1. may be cross-allergenic with penicillin.
2. have a narrower spectrum than penicillin.
3. have a mechanism of action similar to that of penicillin.
4. may cause cholestatic hepatitis.
(1) and (3)
NDEB released questions part 2 set 12
Mechanism of action of Cephalosporins on the bacteria cell
Affects cell wallAnti Infectives
Cephalosporins are
BactericidalAnti Infectives
Each newer generation of cephalosporines has significantly ___1___ gram-negative antimicrobial properties than the preceding one, and a ___2___ maximum activity against gram-positive organisms.
1. greater 2. decreasedAnti Infectives
First generation cephalosporines
Most active against S. aureus, Group A Beta-hemolytic streptococci, and Pneumococcus.Anti Infectives
Second generation cephalosporines
Still have efficacy against gram-postivie organisms but also possess good activity against E. coli and H. influenzae.Anti Infectives
Third generation cephalosporines
Have the broadest spectrum of activity of all cephalosporins and are extremely effective against gram-negative organisms. They are more active against E.coli, Klebsiella pneumoniae, Enterobacter, Salmonella. and Shigella.Anti Infectives
Fourth generation cephalosporines
Effective against Pseudomas aeruginosa.Anti Infectives
Antibiotics containing this betalactam ring are referred to collectively as beta-lactam antibiotics and include the
1. penicillins
2. cephalosporins
3. carbapenems
4. monobactams
All of the above
Anti Infectives
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