Concerning hand-wrist radiographs, which of the following statements is correct?

The hand-wrist radiograph is of little value in orthodontic diagnosis

Bone age is estimated by the presence or absence of osseous centres in particular bones and compared with standards.

Hand-wrist radiographs are a precise measure of progress in skeletal development in normal children.

The information obtained from radiographs alone is enough to make an accurate determination of skeletal age.