The current recommended regimen of antibiotic prophylaxis for a patient with a prosthetic heart valve and an allergy to penicillin is
amoxicillin 2g orally one hour before procedure only
clindamycin 600mg orally one hour before procedure only.
amoxicillin 3g orally one hour before procedure; then 1.5g six hours after initial dose.
erythromycin stearate, 2g orally two hours before procedure only
clindamycin 300mg orally one hour before procedure; then 150mg six hours after initial dose
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