Violation
On the basis of “Socransky’s Modifications of Koch’s Postulates”, the potential pathogens in periodontal disease must possess all of the following EXCEPT
demonstrate a host response, in the form of alteration in the host cellular, not humoral, immune response.
be capable of causing disease in experimental animal models.
demonstrate virulence factors responsible for enabling the organisms to cause periodontal tissue destruction.
be eliminated or decreased in sites that demonstrate clinical resolution of disease with treatment.
be associated with disease, as evidenced by increases in the number of organisms at diseased sites.