Violation
Lipid Theory
based on the fact that anesthetic action is corrclatcd with the oil/gas coefficients. The higher the solubility of ancsthctics is in oil, the greater is the anesthetic potency
anesthetics bind to hydrophobic portion of the ion channel
based on the fact that anesthetic potency is correlated with the ability of anesthctics to inhibit enzynes activity of a pure, soluble protein. Also, attempts to explain thc GABA A receptor is a potential target of anesthctics acton.