Alteration of the intestinal flora by some chemotherapeutic agents can interfere with reabsorption of a contraceptive steroid thus preventing the recirculation of the drug through the enterohepatic circulation. Which of the following can interfere with this mechanism?
1. Codeine.
2. Penicillin V.
3. Acetaminophen
4. Tetracycline.

(1) and (3)

(2) and (4)

(1) (2) (3)

All of the above

(4) only