Which of the following pharmacokinetic change(s) occur(s) with aging? 1. Absorption is altered by a decrease in the gastric pH. 2. Metabolism is decreased by a reduced liver mass. 3. Distribution is altered by a decrease in total body fat. 4. Excretion is reduced because of lessened renal blood flow.
(1) and (3)
(2) and (4)
(1) (2) (3)
All of the above
(4) only
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