MAO inhibitors (i.e., phenelzine and tranylcypromine)

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    should not be used with indirectly acting sympathetic drugs (i.e., Tyramine and anphetamines) and with several other drugs such as opioids, especially meperidine.

  • inhibit the vasoconstrictor response to epinephrine and levonordefrin.

  • increase the vasoconstrictor response to epinephrine, but reduce the tachycardia resulting from epinephrine.

  • have exaggerated effects when given with neuron depleting agents like reserpine and quanethidine.

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