Lipid Theory

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    based on the fact that anesthetic action is corrclatcd with the oil/gas coefficients. The higher the solubility of ancsthctics is in oil, the greater is the anesthetic potency

  • anesthetics bind to hydrophobic portion of the ion channel

  • based on the fact that anesthetic potency is correlated with the ability of anesthctics to inhibit enzynes activity of a pure, soluble protein. Also, attempts to explain thc GABA A receptor is a potential target of anesthctics acton.

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