A 29 year old male patient presents with a moderate, smooth, enlargement of the left foliate papilla. He first noted this change 2 days previously. There was a recent history of severe flu. Which of the following is the most appropriate interpretation and management for this condition?

Such enlargements often occur in this area and the change can be safely ignored.

This is a common site for the development of oral squamous cell carcinoma and a biopsy is urgently indicated.

Lymphoid tissue occurs in this area and it might be enlarged in response to the flu. The area should be reassessed in 2 weeks.

The enlargement is most likely amyloidosis. Further systemic evaluation is required.