A 52-year-old woman has asymptomatic, bilateral, lacy white striae on the buccal mucosa. Which histopathologic finding would best support the clinical diagnosis?

  • Correct answer

    Band-like subepithelial T-lymphocyte infiltrate with basal cell degeneration

  • Intraepithelial acantholysis forming a suprabasal cleft

  • Subepithelial separation with an intact basal layer

  • Noncaseating granulomas in the lamina propria

This question is one of 15 in AFK practice: Oral medicine, pathology and radiology. Test yourself on all of them.

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Explanations

  • Reticular lichen planus shows a band-like infiltrate of T lymphocytes in the superficial lamina propria with liquefaction degeneration of the basal cells. Suprabasal acantholysis is the hallmark of pemphigus vulgaris.

    Source: Neville et al., Oral and Maxillofacial Pathology — oneguy

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