Autoantibodies in pemphigus vulgaris are mainly directed against which target?

  • Correct answer

    Desmoglein 3

  • BP180 (type XVII collagen)

  • Laminin 332

  • Type VII collagen

This question is one of 15 in AFK practice: Oral medicine, pathology and radiology. Test yourself on all of them.

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Explanations

  • Pemphigus vulgaris is caused by autoantibodies to desmosomal desmoglein 3 (with or without desmoglein 1), producing intraepithelial acantholysis. BP180 is a hemidesmosomal antigen targeted in pemphigoid, which produces subepithelial blisters.

    Source: Neville et al., Oral and Maxillofacial Pathology — oneguy

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