A patient taking warfarin requires an antibiotic. Which of the following is most likely to markedly increase the patient's INR?

  • Correct answer

    Metronidazole

  • Penicillin V

  • Clindamycin

  • Cephalexin

This question is one of 15 in AFK practice: Pharmacology, local anesthesia and emergencies. Test yourself on all of them.

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Explanations

  • Metronidazole inhibits hepatic metabolism of warfarin, producing a well-documented and potentially dangerous rise in INR. The other antibiotics have, at most, minor effects on warfarin.

    Source: Little and Falace's Dental Management of the Medically Compromised Patient — oneguy

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