The vasoconstrictor epinephrine in local anesthetic injections must be used cautiously in patients taking all ofthe following antidepressant drugs EXCEPT one in order to avoid transient and significant increases in blood pressure. Which one is the EXCEPTION

  • Correct answer

    Selective serotonin reuptake inhibitors (i.e., Prozac and Paxil)

  • Tricyclic antidepressants (i.e., Elavil)

  • Serotonin and norepinephrine reuptake inhibitors (i.e., Effexor and Cymbalta)

This question is one of 43 in Antidepressants and Antihistamines. Test yourself on all of them.

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Explanations

  • These trvo categories (tricyclic antidepressants and serotonin and norepinephrine reuptake inhihitors) of antidepressant drugs significantly increase norepinephrine levels in tissues. ln rhe presence of a vasoconstrictor administered via a local anesthetic injection, the patient could experience significant elevation of blood pressure due to the vasopressor actions of the combination.

    — oneguy +1 helpful

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