Second generation cephalosporines
Still have efficacy against gram-postivie organisms but also possess good activity against E. coli and H. influenzae.
Effective against Pseudomas aeruginosa.
Have the broadest spectrum of activity of all cephalosporins and are extremely effective against gram-negative organisms. They are more active against E.coli, Klebsiella pneumoniae, Enterobacter, Salmonella. and Shigella.
Most active against S. aureus, Group A Beta-hemolytic streptococci, and Pneumococcus.
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