Barbiturates are metabolized in

Liver

Plasma

Kidney

Lungs

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The length of action can be related to the lipid solubility of barbiturates with the ultrashort being the ___1___ lipid soluble and the long acting having the ___2___ lipid solubility.

1. most 2. least

1. least 2. most

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Barbiturates do NOT possess serious drug dependence potential.

False

True

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The length of hypnotic action of ultrashort-acting barbiturate after a single dose is

5 to 20 minutes

1 to 3 hours

3 to 6 hours

6 to 10 hours

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The length of hypnotic action of Intermediate-acting barbiturate after a single dose is

3 to 6 hours

5 to 20 minutes

1 to 3 hours

6 to 10 hours

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The length of hypnotic action of long-acting barbiturate after a single dose is

6 to 10 hours

5 to 20 minutes

1 to 3 hours

3 to 6 hours

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Ultrashort-acting barbiturates

for induction of general anesthesia

for treating insomnia

for treating certain types ofseizures

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Short-acting barbiturates

for treating insomnia, can be given preoperatively, before a dental appointment, to allay anxiety

for induction of general anesthesia

for treating certain types ofseizures

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Intermediate-acting barbiturates

for treating insomnia, can also be prescribed to relieve anxiety before a dental appointment

for induction of general anesthesia

for treating certain types ofseizures

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Long-acting barbiturates

for treating certain types of seizures; daytime sedation

for induction of general anesthesia

for treating insomnia

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Thiopental (Pentothal)

Ultrashort-acting barbiturate

Short-acting barbiturate

Intermediate-acting barbiturate

Long-acting barbiturate

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Methohexital (Brevital)

Ultrashort-acting barbiturate

Short-acting barbiturate

Intermediate-acting barbiturate

Long-acting barbiturate

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Secobarbital (Seconal)

Short-acting barbiturate

Ultrashort-acting barbiturate

Intermediate-acting barbiturate

Long-acting barbiturate

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Pentobarbital (Nembutal)

Short-acting barbiturate

Ultrashort-acting barbiturate

Intermediate-acting barbiturate

Long-acting barbiturate

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Amobarbital (Amytal)

Intermediate-acting barbiturate

Ultrashort-acting barbiturate

Short-acting barbiturate

Long-acting barbiturate

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Butabarbital (Butisol)

Intermediate-acting barbiturate

Ultrashort-acting barbiturate

Short-acting barbiturate

Long-acting barbiturate

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Phenobarbital (Luminal)

Long-acting barbiturate

Ultrashort-acting barbiturate

Intermediate-acting barbiturate

Short-acting barbiturate

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Mephobarbital (Mebaral)

Long-acting barbiturate

Ultrashort-acting barbiturate

Intermediate-acting barbiturate

Short-acting barbiturate

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Primidone (Mysoline)

Long-acting barbiturate

Ultrashort-acting barbiturate

Intermediate-acting barbiturate

Short-acting barbiturate

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Barbiturates do not possess analgesic properties

True

False

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