Which of the following local anesthetic formulations provides the longest duration of soft-tissue anesthesia?

  • Correct answer

    0.5% bupivacaine with 1:200,000 epinephrine

  • 2% lidocaine with 1:100,000 epinephrine

  • 3% mepivacaine without vasoconstrictor

  • 4% prilocaine without vasoconstrictor

This question is one of 15 in AFK practice: Pharmacology, local anesthesia and emergencies. Test yourself on all of them.

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Explanations

  • Bupivacaine is a long-acting, highly protein-bound amide whose soft-tissue anesthesia can last many hours, making it useful for postoperative pain control. Lidocaine with epinephrine is an intermediate-duration agent.

    Source: Malamed, Handbook of Local Anesthesia — oneguy

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