Protein (Receptor) Theory

based on the fact that anesthetic potency is correlated with the ability of anesthctics to inhibit enzynes activity of a pure, soluble protein. Also, attempts to explain thc GABA A receptor is a potential target of anesthctics acton.

anesthetics bind to hydrophobic portion of the ion channel

based on the fact that anesthetic action is corrclatcd with the oil/gas coefficients. The higher the solubility of ancsthctics is in oil, the greater is the anesthetic potency